Description

5-(Ethylsulfonyl)Picolinonitrile is a high-value, functionalized heterocyclic building block featuring a sulfonyl and a nitrile group on a pyridine core. This compound is critical for advanced organic synthesis, enabling the development of novel molecules with tailored properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for use as a key intermediate in the creation of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A versatile synthon for constructing complex drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Research: Serves as a core structure for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Precursor: Used in the synthesis of specialized ligands, polymers, and liquid crystals due to its electron-withdrawing sulfonyl and reactive nitrile functionalities.
• Chemical Biology Probe Development: Employed to create tool compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring precise functional group manipulation.

Basic Information

Product Name	5-(Ethylsulfonyl)Picolinonitrile
CAS No.	1649454-78-3
Molecular Formula	C8H8N2O2S
Molecular Weight	196.23 g/mol
Synonyms	5-(Ethylsulfonyl)-2-cyanopyridine; 2-Cyano-5-(ethylsulfonyl)pyridine; 5-(Ethylsulfonyl)picolinonitrile; 2-Pyridinecarbonitrile, 5-(ethylsulfonyl)-; Picolinonitrile, 5-(ethylsulfonyl)-; 5-(Ethanesulfonyl)picolinonitrile; 5-(Ethylsulfonyl)-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-(Ethylsulfonyl)Picolinonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.