Description

Benzoic Acid, 4-[(2R,4R)-4-Ethoxy-2-Piperidinyl]-, Methyl Ester, Rel- is a high-purity, stereochemically defined chiral compound. This advanced pharmaceutical intermediate is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring specific stereochemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and cardiovascular drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel, stereospecific Active Pharmaceutical Ingredients (APIs).
• Research & Development: Used in medicinal chemistry for lead optimization and the development of new chemical entities (NCEs).
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in clinical trials.
• Reference Standard: Can be used as an analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Benzoic Acid, 4-[(2R,4R)-4-Ethoxy-2-Piperidinyl]-, Methyl Ester, Rel-
CAS No.	1644667-62-8
Molecular Formula	C16H23NO3
Molecular Weight	277.36 g/mol
Synonyms	rel-(2R,4R)-Methyl 4-(4-ethoxypiperidin-2-yl)benzoate; Methyl 4-[(2R,4R)-4-ethoxy-2-piperidinyl]benzoate; 4-[(2R,4R)-4-Ethoxy-2-piperidinyl]benzoic acid methyl ester; (2R,4R)-Methyl 4-(4-ethoxypiperidin-2-yl)benzoate; CAS 1644667-62-8; Benzoic acid, 4-(4-ethoxy-2-piperidinyl)-, methyl ester, (2R,4R)-rel-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and stereochemical integrity, with specifications typically covering chiral purity (enantiomeric excess), chemical purity, and residual solvents. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.