Description

Methyl 4,5-Difluoro-2-Iodobenzoate is a high-purity, multi-functional aromatic building block designed for advanced synthetic chemistry. Its unique structure, featuring both fluorine and iodine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides where the difluoro-iodo motif is incorporated for biological activity.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic structure.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for metal-catalyzed reactions like Suzuki-Miyaura, Stille, and Negishi couplings to form biaryl structures.
• Fluorine Chemistry Exploration: An essential reagent for studying the effects of fluorine substitution patterns on chemical reactivity and physical properties in organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale commercial batches.

Basic Information

Product Name	Methyl 4,5-Difluoro-2-Iodobenzoate
CAS No.	1640342-92-2
Molecular Formula	C8H5F2IO2
Molecular Weight	298.03 g/mol
Synonyms	Benzoic acid, 4,5-difluoro-2-iodo-, methyl ester; Methyl 4,5-difluoro-2-iodobenzoate; 2-Iodo-4,5-difluorobenzoic acid methyl ester; Methyl 2-iodo-4,5-difluorobenzoate; 4,5-Difluoro-2-iodobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4,5-Difluoro-2-Iodobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.