Description

Spiro[Cyclohexane-1,3'-Pyrrolo[2,3-B]Pyridine]-2',4(1'H)-Dione CAS NO 1638768-64-5 is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic fused-ring structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel, small-molecule therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns to identify new bioactive molecules.
• Process Chemistry Development: Employed in route scouting and optimization studies for the scalable production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and process development.
• Academic Research: Utilized in universities and research institutes for studying structure-activity relationships (SAR) and novel heterocyclic chemistry.

Basic Information

Product Name	Spiro[Cyclohexane-1,3'-Pyrrolo[2,3-B]Pyridine]-2',4(1'H)-Dione
CAS No.	1638768-64-5
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	Spiro[cyclohexane-1,3'-pyrrolo[2,3-b]pyridine]-2',4(1'H)-dione; 1'H-Spiro[cyclohexane-1,3'-pyrrolo[2,3-b]pyridine]-2',4-dione; 1638768-64-5; Spiro(cyclohexane-1,3'-pyrrolo[2,3-b]pyridine)-2',4(1'H)-dione; Spiro-cyclohexane-pyrrolopyridine-dione; Bicyclic spiro lactam intermediate; Pyrrolopyridine spirocyclic derivative.
EINECS	Contact for details

Quality Control

Our Spiro[Cyclohexane-1,3'-Pyrrolo[2,3-B]Pyridine]-2',4(1'H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity (typically ≥95% to ≥98% by HPLC), related substances, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.