Description

5-Azaspiro[2.3]Hexane Hemioxalate is a high-value, nitrogen-containing spirocyclic building block with the CAS number 1638767-88-0. This compound is prized for its unique three-dimensional structure, which is critical for modulating the physicochemical properties and biological activity of advanced molecules. It serves as a key synthetic intermediate for medicinal chemistry researchers and process development scientists in the pharmaceutical industry, particularly in the discovery and optimization of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used to introduce spirocyclic constraints into lead compounds, improving metabolic stability, solubility, and target selectivity.
• Process Chemistry & Scale-up: Employed in the development of robust and scalable synthetic routes for candidate drugs during late-stage research and development.
• Chemical Biology Probes: Serves as a core structure for designing molecular probes to study enzyme function and biological pathways.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides with novel modes of action.
• Academic & Contract Research: Used in university and CRO (Contract Research Organization) settings for exploratory synthetic chemistry and method development.

Basic Information

Product Name	5-Azaspiro[2.3]Hexane Hemioxalate
CAS No.	1638767-88-0
Molecular Formula	C8H11NO5
Molecular Weight	201.18 g/mol
Synonyms	5-Azaspiro[2.3]hexane, hemioxalate salt; 1-Oxa-5-azaspiro[2.3]hexane hemioxalate; 5-Azaspiro[2.3]hexane oxalic acid salt (1:0.5); Azaspirohexane hemioxalate; Spiro[cyclopropane-1,2'-pyrrolidine] hemioxalate; 2-Oxapropellane hemioxalate (derivative); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 5-Azaspiro[2.3]Hexane Hemioxalate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profiles is supplied with each shipment. Our quality protocols are designed to support regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.