Description

Acetic Acid tert-Butyl 3-Carbamimidoylazetidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine scaffold with a carbamimidoyl functional group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting protease inhibition or receptor modulation.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing complex molecular architectures in drug discovery programs, enabling structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The carbamimidoyl (amidine) group makes it a valuable synthon for developing inhibitors of serine or cysteine proteases.
• Library Synthesis for High-Throughput Screening: Used to generate focused chemical libraries for biological screening against various disease targets.
• Peptidomimetic Drug Design: The azetidine ring acts as a constrained scaffold to mimic peptide conformations, aiding in the creation of more stable and bioavailable drug-like molecules.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes to study specific biological pathways and enzyme functions.

Basic Information

Item	Detail
Product Name	Acetic Acid tert-Butyl 3-Carbamimidoylazetidine-1-Carboxylate
CAS No.	1638765-18-0
Molecular Formula	C11H21N3O3
Molecular Weight	243.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-carbamimidoylazetidine; 3-Carbamimidoylazetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-carbamimidoylazetidine-1-carboxylate; 1-Boc-3-carbamimidoylazetidine; Azetidine-3-carboximidamide, 1-(1,1-dimethylethyl) 1,3-dicarbamate (9CI); BOC-Azetidine-3-carboximidamide
EINECS	Contact for details

Quality Control

Our Acetic Acid tert-Butyl 3-Carbamimidoylazetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.