Description

cis-Cyclobutane-1,3-Dicarboxylic Acid Monobenzyl Ester is a high-purity, synthetically valuable chiral building block and pharmaceutical intermediate. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules due to its rigid cyclobutane core and differentiated carboxylic acid functionality. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring precise stereochemistry and molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, receptor modulators, and other small-molecule therapeutics.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Conformationally Restricted Peptides: The cis-cyclobutane scaffold is used to induce specific backbone conformations in peptide-based drug candidates.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polymers with unique thermal and mechanical properties.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides and fungicides with enhanced efficacy and selectivity.
• Chemical Research & Development: A versatile building block for medicinal chemistry programs and methodology development in academic and industrial labs.

Basic Information

Product Name	cis-Cyclobutane-1,3-Dicarboxylic Acid Monobenzyl Ester
CAS No.	1638764-75-6
Molecular Formula	C14H16O4
Molecular Weight	248.28 g/mol
Synonyms	1,3-cis-Cyclobutanedicarboxylic Acid Monobenzyl Ester; Benzyl Hydrogen cis-1,3-Cyclobutanedicarboxylate; Monobenzyl cis-Cyclobutane-1,3-dicarboxylate; cis-1,3-Cyclobutanedicarboxylic Acid Benzyl Ester; (1R,3S)-Cyclobutane-1,3-dicarboxylic Acid Benzyl Ester; (1S,3R)-Cyclobutane-1,3-dicarboxylic Acid Benzyl Ester; BnOCO-cis-CBD; cis-CBD Monobenzyl Ester
EINECS	Contact for details

Quality Control

Our cis-Cyclobutane-1,3-Dicarboxylic Acid Monobenzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is stable under inert atmosphere. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.