Description

2,5-Dioxopyrrolidin-1-Yl 2,4-Dimethoxybenzoate is a high-purity, activated ester derivative of 2,4-dimethoxybenzoic acid, widely used as a key synthetic intermediate. Its primary value lies in its role as an efficient acylating agent, facilitating the formation of amide bonds under mild conditions, which is critical for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in peptide synthesis, bioconjugation, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used as an activated ester for efficient amide bond formation in solid-phase and solution-phase peptide chemistry.
• Bioconjugation: Facilitates the labeling and modification of biomolecules (e.g., proteins, antibodies) for diagnostic and therapeutic applications.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and plant growth regulators.
• Polymer & Material Science: Employed in the synthesis of specialty polymers, dendrimers, and functionalized materials.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and metabolic pathways.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl 2,4-Dimethoxybenzoate
CAS No.	1638612-98-2
Molecular Formula	C15H15NO7
Molecular Weight	321.28 g/mol
Synonyms	2,4-Dimethoxybenzoic Acid N-Hydroxysuccinimide Ester; 2,4-Dimethoxybenzoyloxy Succinimide; N-(2,4-Dimethoxybenzoyloxy)succinimide; N-Succinimidyl 2,4-Dimethoxybenzoate; NHS Ester of 2,4-Dimethoxybenzoic Acid; 2,4-DMB-NHS; 2,4-Dimethoxybenzoyl NHS Ester; 1-[(2,4-Dimethoxybenzoyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our 2,5-Dioxopyrrolidin-1-Yl 2,4-Dimethoxybenzoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, purity by HPLC, and identification. Our quality protocols are designed to meet the stringent requirements of research and development as well as cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.