Description

2-(tert-Butyldimethylsilyl)-1,3-Phenylene Bis(Trifluoromethanesulfonate) is a highly reactive and versatile aryl bis(triflate) building block, protected by a robust tert-butyldimethylsilyl (TBDMS) group. This compound is critical for enabling complex cross-coupling reactions, particularly in the synthesis of advanced pharmaceutical intermediates and functional organic materials. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing sophisticated aromatic scaffolds with precision.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor in Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-couplings for constructing biaryl and heterobiaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific, sterically hindered aromatic backbones.
• Ligand and Catalyst Development: Serves as a building block for synthesizing sophisticated polydentate ligands and organometallic catalysts.
• Material Science: Employed in the creation of organic semiconductors, liquid crystals, and polymers with tailored electronic properties.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or molecular probes for studying biological systems.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-(tert-Butyldimethylsilyl)-1,3-Phenylene Bis(Trifluoromethanesulfonate)
CAS No.	1637638-66-4
Molecular Formula	C14H18F6O6S2Si
Molecular Weight	488.49 g/mol
Synonyms	1,3-Bis(trifluoromethanesulfonyloxy)-2-(tert-butyldimethylsilyl)benzene; 2-(Tert-Butyldimethylsilyl)-1,3-phenylene bis(triflate); 2-(TBDMS)-1,3-Phenylene Bis(OTf); 1,3-Bis(triflyloxy)-2-(tert-butyldimethylsilyl)benzene; 2-(tert-Butyldimethylsilyl)resorcinol bis(trifluoromethanesulfonate); 2-TBDMS-1,3-(OTf)2-Benzene; Aryl Bis(Triflate) TBDMS Protected
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyldimethylsilyl)-1,3-Phenylene Bis(Trifluoromethanesulfonate) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity and identity. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.