Description

Ethyl 6-(Trifluoromethyl)Tetrahydro-2H-Pyran-3-Carboxylate is a high-value fluorinated building block and chiral intermediate, distinguished by its tetrahydro-2H-pyran (oxane) scaffold and trifluoromethyl group. This compound matters for its ability to impart metabolic stability, lipophilicity, and unique electronic properties to target molecules, which is critical in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Active Ingredient Development: Used to create novel herbicides and fungicides with enhanced efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and liquid crystals.
• Fluorine Chemistry Research: An essential reagent for studying the introduction and effects of the CF3 group in organic molecules.
• Asymmetric Synthesis: Utilized in catalytic reactions to construct complex, enantiomerically pure molecular architectures.

Basic Information

Product Name	Ethyl 6-(Trifluoromethyl)Tetrahydro-2H-Pyran-3-Carboxylate
CAS No.	1637310-75-8
Molecular Formula	C9H13F3O3
Molecular Weight	226.19 g/mol
Synonyms	Ethyl 6-(trifluoromethyl)oxane-3-carboxylate; 3-Carbethoxy-6-trifluoromethyltetrahydro-2H-pyran; 6-(Trifluoromethyl)tetrahydro-2H-pyran-3-carboxylic acid ethyl ester; Ethyl 6-(trifluoromethyl)tetrahydropyran-3-carboxylate; 2H-Pyran-3-carboxylic acid, 6-(trifluoromethyl)tetrahydro-, ethyl ester; Ethyl 6-(trifluoromethyl)-3,4,5,6-tetrahydro-2H-pyran-3-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 6-(Trifluoromethyl)Tetrahydro-2H-Pyran-3-Carboxylate is manufactured under strict quality management systems. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and identification by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are available upon request to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat and ignition sources. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.