Description

Azido-Peg20-Alcohol CAS NO 1637297-21-2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group at one terminus and a hydroxyl group at the other. This bifunctionality is critical for creating stable, hydrophilic linkers in bioconjugation and materials science, enabling the coupling of biomolecules, polymers, and surfaces via click chemistry. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and efficient crosslinking strategies.

Application

• Bioconjugation linker for attaching drugs, peptides, or fluorescent dyes to antibodies, proteins, or nanoparticles via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Surface functionalization agent for modifying glass, gold, or polymer surfaces to introduce hydrophilic PEG layers for anti-fouling or specific binding applications.
• Building block for synthesizing complex polymer architectures, such as block copolymers or dendrimers, for drug delivery systems and hydrogel formation.
• Intermediate in the synthesis of lipid-PEG conjugates for stabilizing lipid nanoparticles (LNPs) used in mRNA and siRNA delivery.
• Crosslinker for creating hydrogels with tailored mechanical properties and degradation profiles for tissue engineering and 3D cell culture.
• Tool compound in chemical biology for probing protein interactions or cellular pathways using bioorthogonal chemistry.

Basic Information

Product Name	Azido-Peg20-Alcohol
CAS No.	1637297-21-2
Molecular Formula	C42H85N3O22
Molecular Weight	~1000.1 g/mol
Synonyms	Azido-PEG20-OH; α-Azido-ω-hydroxy-poly(ethylene glycol); N3-PEG20-OH; PEG20-Azide-OH; 20-Unit PEG Azide Alcohol; Azido-Polyethylene Glycol Monomethyl Ether (related); 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
EINECS	Contact for details

Quality Control

Our Azido-Peg20-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity, correct functional group integrity, and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and moisture content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight	~1000 Da
Moisture Content (KF)	≤ 1.0%
Functional Group Integrity	Azide content ≥ 95% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.