Description

1,1-Difluoro-5-Azaspiro[2.3]Hexane is a high-value, fluorinated spirocyclic building block of significant interest in modern synthetic chemistry. Its unique structure, featuring a strained spirocycle and a difluoromethylene group, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine atoms can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials due to its rigid, three-dimensional structure.
• Fluorine Chemistry Exploration: Acts as a valuable probe and building block in academic and industrial research focused on incorporating fluorinated motifs into complex molecules.

Basic Information

Product Name	1,1-Difluoro-5-Azaspiro[2.3]Hexane
CAS No.	1631027-12-7
Molecular Formula	C6H9F2N
Molecular Weight	133.14 g/mol
Synonyms	5-Azaspiro[2.3]hexane, 1,1-difluoro-; 1,1-Difluoro-5-azaspiro[2.3]hexane; Difluoroazaspirohexane; 1,1-Difluoro-5-azaspiro[2,3]hexane; 1631027-12-7; 5-Azaspiro[2.3]hexane,1,1-difluoro-; AS-81259; SCHEMBL23316177
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Every batch of 1,1-Difluoro-5-Azaspiro[2.3]Hexane is analyzed using advanced techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to support cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be sensitive to strong bases and fluorophilic reagents; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.