Description

Propanoic Acid, 3-(1,1-Dimethylethoxy)-2-Hydroxy-, Methyl Ester, (2R)- is a high-purity, chiral organic ester characterized by its specific stereochemistry and functional groups. This compound is a critical advanced pharmaceutical intermediate (API) and a valuable building block in asymmetric synthesis. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the production of complex, optically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting specific biological pathways.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Agrochemical Research: Serves as a precursor in the development of novel, optically active pesticides and herbicides.
• Flavor & Fragrance Industry: Potential use in the synthesis of specific chiral esters that contribute to unique sensory profiles.
• Academic & Industrial R&D: Employed in chemical research for methodology development and the exploration of new catalytic processes.
• Material Science: Can be investigated as a monomer or modifier for creating specialized polymers with tailored properties.

Basic Information

Product Name	Propanoic Acid, 3-(1,1-Dimethylethoxy)-2-Hydroxy-, Methyl Ester, (2R)-
CAS No.	1630860-06-8
Molecular Formula	C9H18O4
Molecular Weight	190.24 g/mol
Synonyms	(2R)-3-(tert-Butoxy)-2-hydroxy-2-methylpropanoic acid methyl ester; Methyl (2R)-3-(tert-butoxy)-2-hydroxy-2-methylpropanoate; (R)-Methyl 3-(tert-butoxy)-2-hydroxy-2-methylpropanoate; (R)-Methyl 2-hydroxy-2-methyl-3-(tert-butoxy)propanoate; (R)-HMBP Methyl Ester; tert-Butyl (R)-2-hydroxy-2-methyl-3-(methoxycarbonyl)propyl ether; (2R)-HMBP Methyl Ester; (R)-HMBP-OMe
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems. Every batch is analyzed to ensure high chemical and enantiomeric purity, with specifications typically covering identity, assay, chiral purity, and related substances. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for each shipment. We support development and commercial projects requiring compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.