Description

Cy7 Carboxylic Acids CAS NO 1628790-40-8 are a class of near-infrared (NIR) fluorescent dyes functionalized with a carboxylic acid group, enabling covalent conjugation to biomolecules and materials. This modification is critical for creating highly specific and stable fluorescent probes for advanced detection and imaging applications. These dyes are essential for researchers and manufacturers in the fields of bioimaging, diagnostics, and pharmaceutical development who require deep-tissue penetration and minimal background interference.

Application

• Bioconjugation and Probe Synthesis: The carboxylic acid moiety allows for covalent attachment to antibodies, peptides, proteins, and oligonucleotides to create targeted fluorescent probes.
• In Vivo and In Vitro Imaging: Used as a key component in developing NIR imaging agents for deep-tissue visualization in preclinical research, including tumor targeting and lymphatic system mapping.
• Diagnostic Assay Development: Incorporated into lateral flow assays, ELISA, and other diagnostic platforms to provide sensitive and specific detection signals.
• Material Science and Sensor Fabrication: Functionalization of nanoparticles, polymers, and surfaces to create smart materials and chemical sensors with optical reporting capabilities.
• Pharmaceutical Research: Employed in drug delivery studies to track the biodistribution and pharmacokinetics of therapeutic compounds.
• Flow Cytometry and Cell Sorting: Conjugated to cell surface markers for the identification and isolation of specific cell populations using NIR channels.

Basic Information

Product Name	Cy7 Carboxylic Acids
CAS No.	1628790-40-8
Molecular Formula	C38H45N2O2+
Molecular Weight	561.79 g/mol
Synonyms	Cy7-COOH; Cyanine7 carboxylic acid; 2-[(1E,3E)-5-[1,1-Dimethyl-3-(4-sulfobutyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene]penta-1,3-dien-1-yl]-1,1-dimethyl-3-(4-sulfobutyl)-1H-benzo[e]indol-3-ium-5-carboxylate; Sulfo-Cy7 carboxylic acid; NIR-797 carboxylic acid derivative; Heptamethine cyanine dye acid; ICG derivative carboxylic acid
EINECS	Contact for details

Quality Control

Our Cy7 Carboxylic Acids are produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and spectrophotometry to verify optical properties. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Dark green to blue-green solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with molecular structure
Purity (HPLC)	≥ 95% (Area %)
Absorption (λmax)	747 - 753 nm
Emission (λmax)	770 - 780 nm
Extinction Coefficient (ε)	≥ 200,000 cm-1M-1
Water Content (KF)	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.