Description

tert-Butyl 1-(Aminomethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and protected amine structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutics, particularly in central nervous system (CNS) and other targeted disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in targeted protein degradation platforms.
• CNS Drug Discovery: Employed in the research of potential therapeutics for neurological disorders, leveraging its spirocyclic scaffold.
• Peptidomimetic Synthesis: Acts as a constrained, non-natural amino acid analog for creating peptide-like molecules with enhanced stability.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 1-(Aminomethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate Hydrochloride
CAS No.	1624261-87-5
Molecular Formula	C13H25ClN2O2
Molecular Weight	276.80 g/mol
Synonyms	6-((tert-Butoxycarbonyl)-1-(aminomethyl)-6-azaspiro[2.5]octane hydrochloride; 1-(Aminomethyl)-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester hydrochloride; 6-Boc-1-(aminomethyl)-6-azaspiro[2.5]octane HCl; tert-Butyl 1-(aminomethyl)-6-azaspiro[2.5]octane-6-carboxylate HCl; 1-(Aminomethyl)spiro[2.5]octan-6-amine-6-carboxylic acid tert-butyl ester hydrochloride; 6-Azaspiro[2.5]octane-6-carboxylic acid, 1-(aminomethyl)-, 1,1-dimethylethyl ester, hydrochloride; 1624261-87-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(Aminomethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical specifications. Our quality commitment supports research and development requiring high-purity intermediates for reliable and reproducible results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.