Description

3-((Trimethylsilyl)Ethynyl)Pyridin-2-Ol CAS NO 1624261-35-3 is a specialized organosilicon building block featuring a pyridinol core functionalized with a trimethylsilyl-protected ethynyl group. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its unique structural motif.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers, ligands, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The protected alkyne group makes it a valuable substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Ligand Synthesis: Utilized for preparing sophisticated chelating ligands used in catalysis and coordination chemistry.
• Chemical Biology Probes: Acts as a starting point for synthesizing molecular probes and tags for studying biological systems.

Basic Information

Product Name	3-((Trimethylsilyl)Ethynyl)Pyridin-2-Ol
CAS No.	1624261-35-3
Molecular Formula	C10H13NOSi
Molecular Weight	191.31 g/mol
Synonyms	2-Hydroxy-3-[(trimethylsilyl)ethynyl]pyridine; 3-(2-Trimethylsilylethynyl)pyridin-2-ol; 3-(Trimethylsilylethynyl)-2-pyridinol; 2-Pyridinol, 3-[(trimethylsilyl)ethynyl]-; 3-(Trimethylsilylethynyl)pyridin-2(1H)-one (tautomer); TMS-Ethynyl Pyridinol; 3-TMS-Ethynyl-2-hydroxypyridine
EINECS	Contact for details

Quality Control

Our production of 3-((Trimethylsilyl)Ethynyl)Pyridin-2-Ol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.