Description

4-(1,3-Dioxolan-2-Yl)-5-Fluoropyridin-3-Ol is a high-purity fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a protected diol and a fluorine substituent, makes it an invaluable building block for constructing complex molecules with precise electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Employed in the synthesis of functionalized polymers and organic electronic materials where the fluoropyridine moiety can tune material properties.
• Chemical Biology: Utilized as a probe or tagging molecule in bioconjugation and target identification studies due to its reactive hydroxyl group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4-(1,3-Dioxolan-2-Yl)-5-Fluoropyridin-3-Ol
CAS No.	1624260-60-1
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	5-Fluoro-4-(1,3-dioxolan-2-yl)pyridin-3-ol; 3-Hydroxy-5-fluoro-4-(1,3-dioxolan-2-yl)pyridine; 4-(1,3-Dioxolan-2-yl)-5-fluoropyridin-3-ol; 5-Fluoro-4-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridin-3-ol (related protected form); Fluoropyridine-dioxolane intermediate; CAS 1624260-60-1
EINECS	Contact for details

Quality Control

Our 4-(1,3-Dioxolan-2-Yl)-5-Fluoropyridin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request, ensuring traceability and regulatory compliance for advanced R&D and pre-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.