Description

Bromo-Peg8-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a bromo terminus and a tert-butyl ester group. This bifunctional linker is critical for introducing PEG spacers and specific reactive handles into target molecules, enhancing solubility and modifying pharmacokinetic properties. It is an essential intermediate for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science, particularly for creating antibody-drug conjugates (ADCs), prodrugs, and functional polymers.

Application

• Pharmaceutical Linker & Conjugation Chemistry: A key building block for synthesizing cleavable or non-cleavable linkers in Antibody-Drug Conjugates (ADCs) and other targeted therapeutics.
• Prodrug Synthesis: Used to attach therapeutic agents via the ester group, creating hydrolyzable prodrugs with improved bioavailability and controlled release profiles.
• Polymer Functionalization: Serves as a monofunctional initiator or terminating agent for creating PEG-based block copolymers with reactive bromo end-groups for further modification.
• Biomolecule Modification: Facilitates the PEGylation (pegylation) of peptides, proteins, and oligonucleotides to increase stability, reduce immunogenicity, and prolong circulation time.
• Surface Engineering & Material Science: Employed to create functional coatings on surfaces (e.g., nanoparticles, biosensors) by providing a PEG spacer layer terminated with a reactive halogen for subsequent coupling.
• Cross-linking Agent: The bromo group can participate in nucleophilic substitution reactions, making it useful as a cross-linker in hydrogel and polymer network formation.
• Organic Synthesis Intermediate: Acts as a versatile synthon in multi-step organic synthesis where a protected carboxylic acid and a halogenated PEG chain are required.

Basic Information

Product Name	Bromo-Peg8-T-Butyl Ester
CAS No.	1623792-00-6
Molecular Formula	C25H49BrO11
Molecular Weight	605.56 g/mol
Synonyms	1-Bromo-3,6,9,12,15,18,21,24-octaoxapentacosan-25-oic acid tert-butyl ester; tert-Butyl 1-bromo-3,6,9,12,15,18,21,24-octaoxapentacosan-25-oate; Bromo-PEG8-t-butyl ester; Br-PEG8-OtBu; α-Bromo-ω-(tert-butoxycarbonyl)octaethylene glycol; tert-Butyl bromo-PEG8-carboxylate; HO-PEG8-OtBu, Bromo derivative; 8-Amino-3,6,9,12,15,18,21,24-octaoxapentacosanoic acid tert-butyl ester (precursor form)
EINECS	Contact for details

Quality Control

Our Bromo-Peg8-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.