Description

Azido-PEG8-t-butyl ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a protected carboxylic acid terminus. This compound is a critical building block in bioconjugation and materials science, enabling the creation of stable, site-specific linkages via click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications ranging from drug delivery system development to surface functionalization.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile spacer and linker for coupling biomolecules (e.g., peptides, antibodies, oligonucleotides) to surfaces, nanoparticles, or other molecules via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• PEGylation Reagent: Used to introduce PEG chains onto drug molecules or therapeutic proteins to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Polymer and Materials Synthesis: Acts as a functional monomer or cross-linker for synthesizing smart hydrogels, functionalized polymers, and biocompatible coatings with tailored properties.
• Diagnostic Probe Development: Facilitates the labeling of targeting agents (like antibodies or aptamers) with fluorescent dyes, radioisotopes, or other detection moieties for diagnostic assays and imaging.
• Surface Modification: Enables the functionalization of nanoparticles, quantum dots, and solid supports (e.g., glass, gold) for creating bioactive interfaces used in biosensors and cell culture substrates.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and the synthesis of chemical probes to study biological processes and protein function.

Basic Information

Product Name	Azido-PEG8-t-butyl ester
CAS No.	1623791-99-0
Molecular Formula	C25H49N3O11
Molecular Weight	567.68 g/mol
Synonyms	1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid tert-butyl ester; Azido-PEG8-OtBu; N3-PEG8-t-butyl ester; tert-Butyl 1-azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate; Azido-PEG8-acid t-butyl ester; 8-Arm PEG Azide t-Butyl Ester (Note: verify structure for multi-arm); Azido-OEG8-OtBu; PEG8 Azide t-Butyl Ester
EINECS	Contact for details

Quality Control

Every batch of Azido-PEG8-t-butyl ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from key characterization methods such as NMR (¹H and ¹³C), HPLC for purity assessment, and mass spectrometry for confirmation of molecular weight. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms (M+Na+ or M+H+)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.