Description

(S)-2,2',3,3'-Tetrahydro-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a high-value, chiral spirobiindane derivative, recognized for its role as a sophisticated ligand precursor in asymmetric catalysis. Its significance lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a key chiral building block for the synthesis of novel asymmetric organocatalysts and ligands for transition metal complexes.
• Precursor in the development of enantioselective catalysts for C-C bond-forming reactions, such as aldol additions and Michael reactions.
• Research and development of chiral stationary phases (CSPs) for analytical and preparative chromatography.
• Intermediate in the synthesis of pharmaceutical active ingredients (APIs) requiring high optical purity.
• Component in the creation of functionalized polymers and advanced organic materials with specific chiral properties.
• Use in academic and industrial research exploring new methodologies in stereoselective synthesis.

Basic Information

Product Name	(S)-2,2',3,3'-Tetrahydro-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1621066-75-8
Molecular Formula	C41H40O2
Molecular Weight	564.76 g/mol
Synonyms	(S)-SpiroBIANOL; (S)-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobiindane-7,7'-diol; (S)-H8-BINOL Derivative; (S)-Tetrahydro-SpiroBIANOL; (S)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol, 6,6'-bis(2,4,6-trimethylphenyl)-; Chiral Spiro Diol Ligand; Spiro[1H-indene-7,7'-diol, 2,2',3,3'-tetrahydro-6,6'-bis(2,4,6-trimethylphenyl)-, (1'S)-
EINECS	Contact for details

Quality Control

Our production of (S)-2,2',3,3'-Tetrahydro-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobi[1H-Indene]-7,7'-Diol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high optical purity, which is critical for catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We support cGMP and ISO compliant documentation for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.