Description

(S)-2,2',3,3'-Tetrahydro-6,6'-Bis[4-(Trifluoromethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a sophisticated chiral ligand and building block of significant interest in advanced organic synthesis and catalysis. Its value lies in its unique spirobiindane core structure, which provides a rigid, three-dimensional framework for inducing high stereoselectivity in chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel active ingredients and high-value specialty chemicals.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand or precursor for transition metal catalysts in enantioselective synthesis.
• Pharmaceutical Intermediate: A key chiral building block in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Material Science Research: Used in the synthesis of chiral organic frameworks or advanced functional materials with specific optical properties.
• Agrochemical Synthesis: Potential application in the development of enantiomerically pure pesticides and herbicides.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry and process development.

Basic Information

Product Name	(S)-2,2',3,3'-Tetrahydro-6,6'-Bis[4-(Trifluoromethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1621066-71-4
Molecular Formula	C35H24F6O2
Molecular Weight	590.56 g/mol
Synonyms	(S)-6,6'-Bis[4-(Trifluoromethyl)phenyl]-1,1'-spirobi[1H-indene]-7,7'-diol; (S)-SPINOL derivative; (S)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol, 6,6'-bis[4-(trifluoromethyl)phenyl]-; Chiral Spirobiindane Diol Ligand; (S)-6,6'-Bis(4-trifluoromethylphenyl)SPINOL; (S)-TFM-SPINOL
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our chiral intermediates. Each batch of (S)-2,2',3,3'-Tetrahydro-6,6'-Bis[4-(Trifluoromethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol is characterized and tested to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing results from chiral HPLC, NMR, and other analytical methods is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere to prevent oxidation. Keep the container sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.