Description

(1S)-2,2',3,3'-Tetrahydro-6,6'-Dimethyl-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a high-purity, chiral spirobiindane derivative with significant utility in advanced organic synthesis. This compound serves as a critical chiral building block and ligand precursor for the development of asymmetric catalysts and pharmaceutical intermediates. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for creating novel, optically active molecules.

Application

• Asymmetric Catalyst Ligand Synthesis: A key precursor for constructing chiral phosphine or diamine ligands used in enantioselective hydrogenation and cross-coupling reactions.
• Pharmaceutical Intermediate: Serves as a sophisticated chiral scaffold in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Research: Used in the synthesis of novel, chiral herbicides and fungicides where specific stereochemistry is required for bioactivity.
• Material Science: Potential building block for chiral polymers or liquid crystals with unique optical properties.
• Academic & Process Chemistry: A valuable tool for methodological studies in organic chemistry and for scaling up complex synthetic routes in process development.

Basic Information

Product Name	(1S)-2,2',3,3'-Tetrahydro-6,6'-Dimethyl-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1621066-64-5
Molecular Formula	C21H22O2
Molecular Weight	306.40 g/mol
Synonyms	(1S)-6,6'-Dimethyl-1,1'-spirobi[indane]-7,7'-diol; (S)-6,6'-Dimethyl-1,1'-spirobi[indane]-7,7'-diol; (1S)-6,6'-Dimethyl-1,1'-spirobi[1H-indene]-7,7'-diol; (S)-Spirobiindane-7,7'-diol derivative; (1S)-Tetrahydro-6,6'-dimethyl-1,1'-spirobi[1H-indene]-7,7'-diol; (S)-Chiral Spirobiindanediol; (1S)-enantiomer of Spirobiindanediol
EINECS	Contact for details

Quality Control

Our (1S)-2,2',3,3'-Tetrahydro-6,6'-Dimethyl-1,1'-Spirobi[1H-Indene]-7,7'-Diol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure consistent high quality and reliable performance in sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which could affect purity and reactivity. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.