Description

3-Azido-L-Alanine HCl is a non-proteinogenic amino acid derivative featuring a reactive azido group, making it a valuable click chemistry reagent and building block for peptide modification. This compound is essential for researchers and manufacturers developing novel bioconjugates, probes, and materials via bioorthogonal chemistry. It is primarily utilized in pharmaceutical R&D, proteomics, and the synthesis of advanced biomaterials.

Application

• Click Chemistry Reagent: Serves as a key building block for Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label or functionalize biomolecules.
• Peptide & Protein Modification: Used to site-specifically introduce azide handles into peptides and proteins for subsequent conjugation with dyes, polymers, or other functional groups.
• Chemical Biology Probes: Enables the synthesis of activity-based probes and tools for studying enzyme function and protein-protein interactions.
• Bioconjugation & ADC Development: A critical intermediate in the design and synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Materials Science: Incorporated into polymer backbones or surfaces to create functional, bio-compatible materials with tailored properties.
• Metabolic Labeling: Potential use as a metabolic precursor for incorporating azide tags into newly synthesized proteins in living cells.

Basic Information

Product Name	3-Azido-L-Alanine HCl
CAS No.	1620171-64-3
Molecular Formula	C3H6N4O2 • HCl
Molecular Weight	166.56 g/mol (Free base: 130.10 g/mol)
Synonyms	(S)-2-Amino-3-azidopropanoic acid hydrochloride; L-3-Azidoalanine hydrochloride; Azido-L-alanine HCl; 3-Azidoalanine HCl; (S)-3-Azidoalanine hydrochloride; 2-Amino-3-azidopropanoic acid hydrochloride (L-form); β-Azido-L-alanine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Azido-L-Alanine HCl is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.