Description

n-[2-[(tert-Butyldimethylsilyl)Oxy]Ethyl]Oxetan-3-Amine is a high-purity, protected amine building block featuring an oxetane ring, designed for advanced synthetic applications. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the oxetane moiety, which can improve metabolic stability and pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker component or a functionalized building block in the construction of bifunctional degrader molecules.
• Peptidomimetic Synthesis: Incorporated into peptide backbones to create analogs with enhanced stability against enzymatic degradation.
• Material Science Precursor: Potential use in synthesizing functionalized polymers or dendrimers with specific amine-reactive sites.
• Chemical Biology Probes: Utilized to create tagged or labeled molecules for studying biological pathways and target engagement.

Basic Information

Product Name	n-[2-[(tert-Butyldimethylsilyl)Oxy]Ethyl]Oxetan-3-Amine
CAS No.	1616924-64-1
Molecular Formula	C11H25NO2Si
Molecular Weight	231.41 g/mol
Synonyms	3-Aminooxetane-3-ethanol, 2-[(tert-butyldimethylsilyl)oxy]ethyl derivative; 2-((tert-Butyldimethylsilyl)oxy)-N-(oxetan-3-yl)ethan-1-amine; Oxetan-3-amine, N-[2-[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-; TBDMS-Oxetan-3-amine Ethanol Derivative; (Oxetan-3-ylamino)ethyl tert-butyldimethylsilyl ether; 1-(Oxetan-3-ylamino)-2-((tert-butyldimethylsilyl)oxy)ethane
EINECS	Contact for details

Quality Control

Our n-[2-[(tert-Butyldimethylsilyl)Oxy]Ethyl]Oxetan-3-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.