Description

Trimethylsilyl Bromodifluoroacetate is a specialized organosilicon reagent featuring a reactive bromodifluoroacetate moiety protected by a trimethylsilyl group. This compound is a valuable synthetic intermediate for the efficient introduction of the difluoromethyl or difluoromethylene unit into target molecules, a critical modification in modern pharmaceutical and agrochemical design. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing difluoromethylene (CF2) groups, which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where fluorination improves activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifying agent in the development of fluorinated polymers and specialty materials with unique surface properties.
• Fluorine Chemistry Research: Essential reagent for method development in organic synthesis, particularly for nucleophilic difluoromethylation and homologation reactions.
• Liquid Crystal & OLED Material Development: Employed to synthesize fluorinated components for electronic displays and organic light-emitting diodes to optimize performance.

Basic Information

Product Name	Trimethylsilyl Bromodifluoroacetate
CAS No.	1613293-20-1
Molecular Formula	C5H9BrF2O2Si
Molecular Weight	223.11 g/mol
Synonyms	Bromodifluoroacetic Acid Trimethylsilyl Ester; (Bromodifluoroacetoxy)trimethylsilane; Trimethylsilyl Bromodifluoroethanoate; TMS-Bromodifluoroacetate; Silane, [(bromodifluoroacetyl)oxy]trimethyl-; Bromodifluoroacetic Acid TMS Ester; 2-Bromo-2,2-difluoroacetic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Bromodifluoroacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.