Description

5-(tert-Butoxycarbonyl)-5-Azaspiro[2.4]Heptane-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amine structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and novel drug candidates, offering a versatile building block for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) therapeutics, antiviral agents, and other specialized small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex Active Pharmaceutical Ingredients (APIs) and new chemical entities (NCEs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or ligand design for targeted protein degradation therapeutics.
• CNS Drug Synthesis: Employed in the research and production of potential therapeutics for neurological and psychiatric disorders.
• Antiviral Agent Development: Utilized as a precursor in the creation of novel antiviral compounds.
• Peptidomimetic Chemistry: The spirocyclic structure is valuable for constructing conformationally constrained peptide analogs.
• Contract Manufacturing (CMO/CDMO): Supplied to outsourcing partners for cGMP-scale production of clinical trial materials and commercial APIs.

Basic Information

Product Name	5-(tert-Butoxycarbonyl)-5-Azaspiro[2.4]Heptane-4-Carboxylic Acid
CAS No.	1613292-78-6
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	5-((tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-4-carboxylic acid; 5-Boc-5-azaspiro[2.4]heptane-4-carboxylic acid; 4-Carboxy-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester; 5-Azaspiro[2.4]heptane-4-carboxylic acid, 5-(1,1-dimethylethyl) ester; tert-Butyl 4-carboxy-5-azaspiro[2.4]heptane-5-carboxylate; Boc-5-azaspiro[2.4]heptane-4-COOH; 1613292-78-6
EINECS	Contact for details

Quality Control

Our 5-(tert-Butoxycarbonyl)-5-Azaspiro[2.4]Heptane-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.