Description

((2S,3S,4R,5R)-3-(Benzoyloxy)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)-2,4-Difluorotetrahydrofuran-2-Yl)Methyl Benzoate CAS NO 1612841-23-2 is a high-purity, fluorinated nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the creation of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular replication mechanisms. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the synthesis of next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluorinated nucleoside analog prodrugs and antiviral agents.
• Antiviral Drug Development: Research and production of potential therapeutics for viruses such as hepatitis C (HCV), influenza, and other RNA viruses.
• Oncology Research: Used in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving polymerases and kinases.
• Process Chemistry: Employed in route scouting and scale-up processes for the commercial manufacturing of complex APIs.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	((2S,3S,4R,5R)-3-(Benzoyloxy)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)-2,4-Difluorotetrahydrofuran-2-Yl)Methyl Benzoate
CAS No.	1612841-23-2
Molecular Formula	C24H18F2N2O7
Molecular Weight	484.41 g/mol
Synonyms	1-((2S,3S,4R,5R)-3-(Benzoyloxy)-2,4-difluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 2',3'-Dibenzoate; 2',3'-Di-O-benzoyl-2',3'-dideoxy-2',3'-difluoro-5-fluorouridine; 2',3'-Dideoxy-2',3'-difluoro-5-fluorouridine 2',3'-dibenzoate; Fluorinated uridine derivative intermediate; 5-Fluoro-2',3'-dideoxy-2',3'-difluorouridine dibenzoate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting full compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.