Description

Azd-Peg5 -Pfp is a specialized bifunctional PEG linker featuring an azide group and a pentafluorophenyl (PFP) ester. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient and selective coupling of biomolecules and synthetic polymers. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as antibody-drug conjugate (ADC) development, peptide modification, and polymer functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key intermediate for connecting cytotoxic payloads to monoclonal antibodies via the azide-alkyne cycloaddition (click) reaction and subsequent PFP ester coupling.
• Peptide and Protein Modification: Enables site-specific labeling, PEGylation, and cross-linking of peptides and proteins to enhance stability, solubility, or therapeutic properties.
• Polymer Functionalization: Used to introduce reactive azide or activated ester groups into polymer backbones for creating advanced functional materials and hydrogels.
• Bioconjugation Reagent: Facilitates the covalent attachment of various molecules (e.g., dyes, drugs, ligands) to biomolecules for diagnostic and therapeutic applications.
• Surface Immobilization: Assists in the functionalization of surfaces and nanoparticles for biosensor development and targeted drug delivery systems.
• Chemical Biology Tool: A versatile probe for studying biomolecular interactions and metabolic pathways through bioorthogonal chemistry strategies.

Basic Information

Product Name	Azd-Peg5 -Pfp
CAS No.	1609569-75-6
Molecular Formula	C24H31F5N4O8
Molecular Weight	598.52 g/mol
Synonyms	Azido-PEG5-PFP ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate, Pentafluorophenyl ester; 1-Azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid pentafluorophenyl ester; Azido-PEG5-PFP; N3-PEG5-PFP ester; Azido-Penta(ethylene glycol)-PFP Ester; Azido-PEG5-Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our Azd-Peg5 -Pfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maintain stability. The product is hygroscopic and moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or viscous liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.