Description

2-Methylbenzofuro[2,3-B]Pyridin-8-Yl Trifluoromethanesulfonate is a high-purity, advanced pharmaceutical intermediate featuring a reactive triflate leaving group. This compound is of significant value for its role in facilitating efficient cross-coupling reactions, enabling the synthesis of complex heterocyclic scaffolds. It is primarily sought after by research organizations and pharmaceutical developers engaged in medicinal chemistry and the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile reactivity in palladium-catalyzed coupling reactions (e.g., Suzuki, Negishi).
• Organic Synthesis: Serves as a critical precursor for constructing complex benzofuropyridine derivatives and other fused heterocyclic systems in academic and industrial R&D.
• Agrochemical Development: Potential intermediate in the research and synthesis of new generation herbicides and fungicides with specific biological activity.
• Material Science: Exploration of its use in creating organic electronic materials and photoactive compounds due to its conjugated structure.

Basic Information

Product Name	2-Methylbenzofuro[2,3-B]Pyridin-8-Yl Trifluoromethanesulfonate
CAS No.	1609373-98-9
Molecular Formula	C14H10F3NO4S
Molecular Weight	345.30 g/mol
Synonyms	2-Methyl-8-(trifluoromethanesulfonyloxy)benzofuro[2,3-b]pyridine; 2-Methylbenzofuro[2,3-b]pyridin-8-yl triflate; 8-Triflyloxy-2-methylbenzofuro[2,3-b]pyridine; 2-Methyl-8-trifluoromethanesulfonyloxybenzofuro[2,3-b]pyridine; Trifluoromethanesulfonic acid 2-methylbenzofuro[2,3-b]pyridin-8-yl ester; 2-Methylbenzofuro[2,3-b]pyridin-8-ol triflate; 1609373-98-9
EINECS	Contact for details

Quality Control

Our 2-Methylbenzofuro[2,3-B]Pyridin-8-Yl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.