Description

Trimethyl((Tetrahydro-2H-Pyran-4-Yl)Ethynyl)Silane is a specialized organosilicon building block featuring a silyl-protected alkyne group tethered to a tetrahydropyran ring. This unique molecular architecture makes it a valuable intermediate for constructing complex molecules in pharmaceutical and advanced materials research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry and organic synthesis. The compound's reactivity allows for selective functionalization, enabling the synthesis of novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the tetrahydropyran moiety and alkyne functionality via click chemistry or cross-coupling reactions.
• Medicinal Chemistry: Used in drug discovery programs for the structure-activity relationship (SAR) exploration and the creation of compound libraries targeting various disease pathways.
• Organic Synthesis Reagent: Serves as a versatile reagent in organic synthesis for constructing complex molecular scaffolds, leveraging the reactivity of the protected alkyne group.
• Material Science Research: Employed in the development of novel polymers, dendrimers, or surface modifiers where the silane and alkyne groups can be utilized for further chemical grafting or polymerization.
• Agrochemical Synthesis: Potential intermediate in the research and development of new agrochemicals requiring specific heterocyclic and alkyne components.

Basic Information

Product Name	Trimethyl((Tetrahydro-2H-Pyran-4-Yl)Ethynyl)Silane
CAS No.	1604039-54-4
Molecular Formula	C₁₀H₁₈OSi
Molecular Weight	182.34 g/mol
Synonyms	Trimethyl(2-(tetrahydro-2H-pyran-4-yl)ethynyl)silane; (Tetrahydro-2H-pyran-4-ylethynyl)trimethylsilane; 4-((Trimethylsilyl)ethynyl)tetrahydro-2H-pyran; 4-Ethynyltetrahydro-2H-pyran, trimethylsilyl derivative; Silane, trimethyl[(tetrahydro-2H-pyran-4-yl)ethynyl]-; 1604039-54-4
EINECS	Contact for details

Quality Control

Our Trimethyl((Tetrahydro-2H-Pyran-4-Yl)Ethynyl)Silane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, GC, and HPLC, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.