Description

5-Fluorospiro[1H-Indole-3,4'-Oxane]-2-One is a high-value, fluorinated spirocyclic indole derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique spirocyclic architecture, incorporating both indole and oxane motifs, makes it a versatile building block for constructing complex molecular frameworks. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, leveraging the bioactivity of the fluorinated indole structure.
• Material Science Precursor: Serves as a building block for advanced organic materials, including specialty polymers and liquid crystals.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in synthetic organic chemistry and medicinal chemistry.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of fluorine substitution on the reactivity and properties of spirocyclic systems.

Basic Information

Product Name	5-Fluorospiro[1H-Indole-3,4'-Oxane]-2-One
CAS No.	1603067-38-4
Molecular Formula	C₁₂H₁₂FNO₂
Molecular Weight	221.23 g/mol
Synonyms	5-Fluoro-1H-spiro[indole-3,4'-oxane]-2-one; 5-Fluoro-1H-spiro[indole-3,4'-oxan]-2-one; 5-Fluoro-1H-spiro[indole-3,4'-oxane]-2(3H)-one; 5-Fluorospiro[indoline-3,4'-oxane]-2-one; 5-Fluorospiro[1H-indole-3,4'-oxane]-2(3H)-one; 1603067-38-4; Spiro[1H-indole-3,4'-oxane]-2-one, 5-fluoro-
EINECS	Contact for details

Quality Control

Our 5-Fluorospiro[1H-Indole-3,4'-Oxane]-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and scale-up projects with material that meets rigorous in-house specifications, suitable for use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.