Description

Cyclobutanecarboxylic Acid, 3-(Hydroxymethyl)-, Phenylmethyl Ester, trans- is a high-purity, chiral synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a sophisticated building block in the synthesis of complex, biologically active molecules, enabling precise control over stereochemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries working on novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), particularly in oncology, neurology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is crucial for efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance and flavor compounds.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis and medicinal chemistry programs.
• Peptidomimetic Research: The trans-cyclobutane scaffold is utilized in the design of conformationally constrained peptide analogs.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-(Hydroxymethyl)-, Phenylmethyl Ester, trans-
CAS No.	1602652-31-2
Molecular Formula	C13H16O3
Molecular Weight	220.26 g/mol
Synonyms	trans-Benzyl 3-(hydroxymethyl)cyclobutanecarboxylate; Benzyl trans-3-(hydroxymethyl)cyclobutanecarboxylate; (1r,3r)-3-(Hydroxymethyl)cyclobutanecarboxylic Acid Benzyl Ester; (1s,3s)-3-(Hydroxymethyl)cyclobutanecarboxylic Acid Benzyl Ester; trans-3-(Hydroxymethyl)cyclobutanecarboxylic Acid Benzyl Ester; Bn-3-HMCB; Benzyl trans-HMCBC
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-(Hydroxymethyl)-, Phenylmethyl Ester, trans- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.