Description

6-Bromo-2-Fluoro-3-Iodopyridine is a high-purity, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as catalyst ligand synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the halogen atoms provide sites for further functionalization.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating novel ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or components for OLEDs, due to its electron-deficient pyridine core.
• Chemical Biology Probes: Acts as a starting material for synthesizing tagged molecules or probes used in biochemical assays and diagnostic research.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for sequential Suzuki, Stille, and Negishi cross-coupling reactions to build complex biaryl systems.

Basic Information

Product Name	6-Bromo-2-Fluoro-3-Iodopyridine
CAS No.	1599474-54-0
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	3-Iodo-6-bromo-2-fluoropyridine; 2-Fluoro-3-iodo-6-bromopyridine; 6-Bromo-2-fluoro-3-iodopyridine; Pyridine, 6-bromo-2-fluoro-3-iodo-; 1599474-54-0; 6-Br-2-F-3-I-pyridine
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2-Fluoro-3-Iodopyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and mass spectrometry is supplied with each shipment to guarantee reproducible results and supply chain reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.