Description

1-Oxa-3,9-Diazaspiro[5.5]Undecan-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant interest in modern drug discovery. Its unique spirocyclic structure containing both ether and amine functionalities makes it a valuable scaffold for medicinal chemistry, particularly in the development of novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs) and new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of potential APIs, leveraging its spirocyclic core for conformational restriction and improved pharmacokinetic properties.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clinical trials.

Basic Information

Product Name	1-Oxa-3,9-Diazaspiro[5.5]Undecan-2-One Hydrochloride
CAS No.	1598381-36-2
Molecular Formula	C9H17ClN2O2
Molecular Weight	220.70 g/mol
Synonyms	1-Oxa-3,9-diazaspiro[5.5]undecan-2-one, hydrochloride; 1-Oxa-3,9-diazaspiro[5.5]undecan-2-one HCl; 2-Oxo-1-oxa-3,9-diazaspiro[5.5]undecane hydrochloride; Spirocyclic ether-amine hydrochloride; CAS 1598381-36-2
EINECS	Contact for details

Quality Control

Our 1-Oxa-3,9-Diazaspiro[5.5]Undecan-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.