Description

(3R,4R)-1-(4-Fluorophenyl)-3-((R)-3-(4-Fluorophenyl)-3-Hydroxypropyl)-4-(4-Hydroxyphenyl)Azetidin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant commercial importance as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents, particularly in areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of proprietary drug candidates.
• API Development: Used in research and process chemistry for constructing the core scaffold of potential new chemical entities (NCEs).
• Asymmetric Synthesis: Employed in reactions requiring high enantioselectivity due to its defined (3R,4R,R) stereochemistry.
• Medicinal Chemistry Research: Provides a versatile template for structure-activity relationship (SAR) studies and lead optimization.
• Process Scale-up: Supplied in development and commercial quantities for scaling pharmaceutical manufacturing processes.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Item	Details
Product Name	(3R,4R)-1-(4-Fluorophenyl)-3-((R)-3-(4-Fluorophenyl)-3-Hydroxypropyl)-4-(4-Hydroxyphenyl)Azetidin-2-One
CAS No.	1593542-96-1
Molecular Formula	C24H21F2NO3
Molecular Weight	409.43 g/mol
Synonyms	(3R,4R)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; Ezetimibe related compound (stereoisomer); (3R,4R)-4-(4-Hydroxyphenyl)-1-(4-fluorophenyl)-3-[(1R)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone; Azetidin-2-one derivative; Fluorophenyl hydroxypropyl azetidinone isomer.
EINECS	Contact for details

Quality Control

Our (3R,4R)-1-(4-Fluorophenyl)-3-((R)-3-(4-Fluorophenyl)-3-Hydroxypropyl)-4-(4-Hydroxyphenyl)Azetidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing purity, impurities, and chiral excess are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.