Description

1-Azetidinecarboxylic Acid, 3-(Carboxymethoxy)-3-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester is a sophisticated, multi-functional organic building block designed for advanced synthetic chemistry. This compound is of significant value for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for constructing constrained peptide mimetics and heterocyclic scaffolds.
• Peptidomimetic Research: Used to introduce the azetidine carboxylic acid moiety, a valuable proline surrogate, into peptide chains to modulate biological activity, stability, and pharmacokinetic properties.
• Protecting Group Chemistry: The 9-Fluorenylmethyl (Fm) ester group serves as a base-labile protecting group for carboxylic acids in multi-step organic synthesis, commonly employed in solid-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Utilized in the development of activity-based probes and labeled compounds for studying enzyme function and biological pathways.
• Agrochemical Synthesis: Acts as an intermediate in the research and development of new herbicides, fungicides, and plant growth regulators with novel modes of action.
• Material Science: Potential monomer or cross-linker for creating specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	1-Azetidinecarboxylic Acid, 3-(Carboxymethoxy)-3-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester
CAS No.	1592739-14-4
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	3-(Carboxymethoxy)-3-methylazetidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; Fmoc-Aze(3-(OMe)-OH); 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-3-((methoxycarbonyl)oxy)-3-methylazetidine-3-carboxylic acid (common name variant); 9-Fluorenylmethyl 3-(methoxycarbonyloxy)-3-methylazetidine-1-carboxylate; Fmoc-3-methyl-3-(carboxymethoxy)azetidine; Azetidine-3-carboxylic acid, 3-(carboxymethoxy)-3-methyl-, 1-(9H-fluoren-9-ylmethyl) ester; CAS 1592739-14-4
EINECS	Contact for details

Quality Control

Our 1-Azetidinecarboxylic Acid, 3-(Carboxymethoxy)-3-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.