Description

(2S,3S,5R,6R)-5,6-Bis(Azidomethyl)-2,3-Dimethoxy-2,3-Dimethyl-1,4-Dioxane is a high-value, stereochemically defined azido-functionalized dioxane derivative. This compound serves as a critical chiral building block and click chemistry reagent, enabling the efficient synthesis of complex molecules through copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral and antibiotic research.
• Click Chemistry Reagent: Enables bioorthogonal conjugation and labeling of biomolecules, polymers, and surfaces in chemical biology and materials science.
• Agrochemical Research: Used in the development of new, stereoselective pesticides and herbicides.
• Polymer Modification: Incorporates azide functionality into polymer backbones or side chains for crosslinking or introducing new properties.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts.
• Academic & R&D: Fundamental research tool in synthetic organic chemistry for constructing complex, oxygen-containing heterocycles.

Basic Information

Product Name	(2S,3S,5R,6R)-5,6-Bis(Azidomethyl)-2,3-Dimethoxy-2,3-Dimethyl-1,4-Dioxane
CAS No.	1585236-34-5
Molecular Formula	C₁₀H₁₈N₆O₄
Molecular Weight	286.29 g/mol
Synonyms	5,6-Bis(azidomethyl)-2,3-dimethoxy-2,3-dimethyl-1,4-dioxane (2S,3S,5R,6R)-; (2S,3S,5R,6R)-2,3-Dimethoxy-2,3-dimethyl-5,6-bis(azidomethyl)-1,4-dioxane; 1,4-Dioxane, 5,6-bis(azidomethyl)-2,3-dimethoxy-2,3-dimethyl-, (2S,3S,5R,6R)-; Azido-functionalized dioxane; Chiral bis-azido dioxane; Click chemistry dioxane building block; CAS 1585236-34-5
EINECS	Contact for details

Quality Control

Our production of (2S,3S,5R,6R)-5,6-Bis(Azidomethyl)-2,3-Dimethoxy-2,3-Dimethyl-1,4-Dioxane adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is light-sensitive and easily oxidized; avoid exposure to direct light, heat, and oxidizing agents. Allow the container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.