Description

5-Iodo-2-Methylamino-Nicotinic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly in medicinal chemistry for creating targeted therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially in oncology and CNS research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Employed in the research and process development stages for creating new active pharmaceutical ingredients.
• Chemical Synthesis: Serves as a specialized reagent for introducing the iodo-methylamino-nicotinate moiety into more complex molecular architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process scale-up services for the pharmaceutical industry.

Basic Information

Product Name	5-Iodo-2-Methylamino-Nicotinic Acid tert-Butyl Ester
CAS No.	1556958-94-1
Molecular Formula	C12H17IN2O2
Molecular Weight	348.18 g/mol
Synonyms	tert-Butyl 5-iodo-2-(methylamino)nicotinate; 2-(Methylamino)-5-iodonicotinic Acid tert-Butyl Ester; 5-Iodo-2-(methylamino)pyridine-3-carboxylic Acid tert-Butyl Ester; Nicotinic acid, 5-iodo-2-(methylamino)-, 1,1-dimethylethyl ester; 1556958-94-1; tert-Butyl 5-iodo-2-(methylamino)pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-Methylamino-Nicotinic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.