Description

Ethyl 2-Cyclopropyl-2,2-Difluoroacetate is a high-value fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring a cyclopropyl ring and a difluoroacetate ester group, makes it a critical intermediate for introducing fluorinated motifs into target molecules. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of fluorinated drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorinated cyclopropyl moiety can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced materials requiring fluorinated components for specific thermal or chemical resistance properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, esterifications, and ring-opening transformations to construct complex molecular architectures in academic and industrial research.
• Ligand and Catalyst Development: Utilized in the synthesis of novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Ethyl 2-Cyclopropyl-2,2-Difluoroacetate
CAS No.	1556219-70-5
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	2-Cyclopropyl-2,2-difluoroacetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-cyclopropylacetate; Difluoro(cyclopropyl)acetic Acid Ethyl Ester; Ethyl Cyclopropanecarbodifluoroacetate; Ethyl α,α-Difluorocyclopropylacetate; Acetic acid, 2-cyclopropyl-2,2-difluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Cyclopropyl-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and GC-MS and NMR for identity and impurity profiling, to ensure it meets the stringent requirements of synthesis applications. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.