Description

4-Azido-2-(Fmoc-Amino)-Butanoic Acid is a specialized, high-purity building block designed for advanced peptide synthesis and bioconjugation. This compound is critical for introducing azido functional groups into peptide chains, enabling subsequent click chemistry reactions for labeling, crosslinking, and material functionalization. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as an Fmoc-protected amino acid derivative for the site-specific incorporation of azide handles into synthetic peptides.
• Bioconjugation and Click Chemistry: The azido group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkynes, enabling efficient labeling of proteins, antibodies, and other biomolecules.
• Chemical Biology Probes: Serves as a key intermediate in the synthesis of activity-based probes and photoaffinity labels for studying protein function and interactions.
• Drug Discovery & Development: Employed in the synthesis of peptide-drug conjugates (PDCs) and for modifying therapeutic peptides to improve stability, targeting, or pharmacokinetic properties.
• Material Science: Used to functionalize surfaces and polymers with bio-recognition elements for biosensor and diagnostic device development.

Basic Information

Product Name	4-Azido-2-(Fmoc-Amino)-Butanoic Acid
CAS No.	1554468-65-3
Molecular Formula	C19H18N4O4
Molecular Weight	366.37 g/mol
Synonyms	Fmoc-Asp(N3)-OH; Fmoc-L-Aspartic acid 4-azide; Fmoc-Aspartic acid β-azide; N-α-Fmoc-L-aspartic acid 4-azide; 4-Azido-L-aspartic acid N-α-Fmoc derivative; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-azidobutanoic acid; Fmoc-Asp(N3); Fmoc-L-Asp(N3)-OH
EINECS	Contact for details

Quality Control

Our 4-Azido-2-(Fmoc-Amino)-Butanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high standards suitable for pharmaceutical R&D and can provide material with custom specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.