Description

tert-Butyl 4-Amino-1-Azaspiro[4.4]Nonane-1-Carboxylate is a protected amino acid derivative and a key spirocyclic building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and chemical probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space afforded by the spirocyclic scaffold.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for potential APIs.
• Chemical Biology: Employed in the design and synthesis of chemical probes and tool compounds for biological target validation.
• Custom Synthesis: A versatile precursor for contract research and manufacturing organizations (CROs/CMOs) producing bespoke molecules for clients.

Basic Information

Product Name	tert-Butyl 4-Amino-1-Azaspiro[4.4]Nonane-1-Carboxylate
CAS No.	1545158-39-1
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	1-Boc-4-Amino-1-azaspiro[4.4]nonane; 4-Amino-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-amino-1-azaspiro[4.4]nonane; Boc-4-Amino-1-azaspiro[4.4]nonane; tert-Butyl 4-amino-1-azaspiro[4.4]nonane-1-carboxylate; 1-Azaspiro[4.4]nonane-1-carboxylic acid, 4-amino-, 1,1-dimethylethyl ester; 1545158-39-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-1-Azaspiro[4.4]Nonane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.