Description

Methyl 5-Hydroxypiperidine-2-Carboxylate is a high-purity piperidine derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the functional versatility provided by the hydroxymethyl and ester groups, enabling precise molecular construction. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new drug candidates, including protease inhibitors, neurological agents, and anti-infectives.
• Agrochemical Synthesis: Building block for creating advanced pesticides and herbicides with specific stereochemical requirements.
• Chemical Research: Versatile starting material in academic and industrial R&D for exploring new synthetic methodologies and heterocyclic chemistry.
• Peptidomimetics: Used in the design and synthesis of peptide analogs and conformationally constrained scaffolds for medicinal chemistry.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	Methyl 5-Hydroxypiperidine-2-Carboxylate
CAS No.	1538221-90-7
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	Methyl 5-hydroxypiperidine-2-carboxylate; 5-Hydroxypiperidine-2-carboxylic acid methyl ester; Methyl 5-hydroxypipecolate; 2-Piperidinecarboxylic acid, 5-hydroxy-, methyl ester; Methyl (5-hydroxy-2-piperidinyl)carboxylate; 5-Hydroxy-L-pipecolic acid methyl ester; (2S)-5-Hydroxypiperidine-2-carboxylic acid methyl ester (for enantiomer); Contact for details on specific stereoisomers.
EINECS	Contact for details

Quality Control

Our Methyl 5-Hydroxypiperidine-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity and impurity profile analysis via HPLC and GC. Certificates of Analysis (COA) detailing identity, purity, and specific tests are available for every batch upon request, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specific enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.