Description

4,4-Difluoro-2,2-Dimethylbutanoic Acid is a high-value fluorinated carboxylic acid building block, distinguished by its gem-dimethyl and terminal difluoromethylene groups. This unique structure offers enhanced metabolic stability and lipophilicity, making it a critical intermediate for advanced material and life science research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in protease inhibitors and other small molecule therapeutics where fluorine substitution modulates bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoro-dimethyl moiety can improve environmental stability and target specificity.
• Material Science: Serves as a precursor for fluorinated polymers, liquid crystals, and specialty surfactants that require specific solubility and surface energy properties.
• Chemical Biology Probes: Employed in the design of activity-based probes and fluorinated analogs of natural products for metabolic pathway studies.
• Peptidomimetics: Incorporated into peptide backbones to enhance conformational rigidity and resistance to enzymatic degradation.

Basic Information

Product Name	4,4-Difluoro-2,2-Dimethylbutanoic Acid
CAS No.	1536988-56-3
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	2,2-Dimethyl-4,4-difluorobutanoic Acid; 4,4-Difluoro-2,2-dimethylbutyric Acid; 4,4-Difluoro-2,2-dimethyl-butyric Acid; Butanoic acid, 4,4-difluoro-2,2-dimethyl-; 1536988-56-3; 4,4-Difluoro-2,2-dimethylbutanoate
EINECS	Contact for details

Quality Control

Every batch of 4,4-Difluoro-2,2-Dimethylbutanoic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and sources of fluoride ions. The container must be kept tightly sealed due to the compound's sensitivity to moisture and potential reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.