Description

Ethyl 2-Amino-2-Cyclobutylacetate is a high-purity chiral building block and ester derivative of a non-proteinogenic amino acid, essential for advanced pharmaceutical synthesis and chemical research. Its unique cyclobutyl structure provides a valuable scaffold for constructing complex molecules with constrained geometries, enabling the development of novel active pharmaceutical ingredients (APIs) and bioactive compounds. This intermediate is critical for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to innovate in drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral drugs.
• Peptidomimetics Research: Serves as a constrained amino acid analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Agrochemical Active Ingredient Development: Used in the research and production of advanced herbicides, fungicides, and insecticides with novel modes of action.
• Asymmetric Synthesis Catalyst Ligand: Employed as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical and Specialty Chemical Production: A versatile building block for creating custom compounds and high-value specialty chemicals.
• Academic and R&D Laboratories: Used in university and corporate research settings for methodological studies and exploring new chemical spaces.

Basic Information

Product Name	Ethyl 2-Amino-2-Cyclobutylacetate
CAS No.	1536099-38-3
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	2-Amino-2-cyclobutylacetic acid ethyl ester; Ethyl α-aminocyclobutaneglycolate; Ethyl 2-aminocyclobutaneacetate; Cyclobutylglycine ethyl ester; (Aminocyclobutyl)acetic acid ethyl ester; Ethyl (aminocyclobutyl)acetate; 2-Cyclobutyl-2-aminoacetate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-2-Cyclobutylacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.