Description

Methyl 3-Bromo-5-Fluoro-4-Methylbenzoate is a high-purity, multi-functional aromatic ester building block of significant importance in advanced organic synthesis. Its molecular structure, featuring bromo and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides, where the halogenated aromatic core contributes to biological activity and metabolic stability.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify molecular polarity and intermolecular interactions.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl structures.
• Fluorine Chemistry: The presence of the fluorine atom allows for studies in fluorination chemistry and the development of compounds with improved bioavailability and membrane permeability.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Methyl 3-Bromo-5-Fluoro-4-Methylbenzoate
CAS No.	1533932-57-8
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	3-Bromo-5-fluoro-4-methylbenzoic acid methyl ester; Methyl 3-bromo-5-fluoro-p-toluate; Benzoic acid, 3-bromo-5-fluoro-4-methyl-, methyl ester; 4-Methyl-3-bromo-5-fluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Bromo-5-Fluoro-4-Methylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.