Description

Methyl-5-Bromo-4-Iodonicotinic Acid is a high-purity, multi-halogenated nicotinic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an invaluable intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Building block for developing new generation herbicides, fungicides, and plant growth regulators with specific modes of action.
• Ligand Synthesis: Used in the preparation of complex ligands for catalysis and material science applications.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological pathways and protein interactions.
• Material Science: Intermediate for synthesizing functionalized organic molecules used in electronic materials and organic semiconductors.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings due to its bromo and iodo substituents.

Basic Information

Product Name	Methyl-5-Bromo-4-Iodonicotinic Acid
CAS No.	1529795-01-4
Molecular Formula	C7H5BrINO2
Molecular Weight	341.93 g/mol
Synonyms	5-Bromo-4-iodonicotinic acid methyl ester; Methyl 5-bromo-4-iodopyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-bromo-4-iodo-, methyl ester; 5-Bromo-4-iodo-3-pyridinecarboxylic acid methyl ester; Methyl 5-bromo-4-iodonicotinate; 1529795-01-4; Methyl ester of 5-bromo-4-iodonicotinic acid
EINECS	Contact for details

Quality Control

Our Methyl-5-Bromo-4-Iodonicotinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC-MS, and NMR for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with each shipment, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.