Description

3-Chloro-4-Fluoro-5-Nitro-Benzoic Acid Methyl Ester is a high-purity, multi-functional chemical intermediate designed for advanced synthesis. Its unique halogenated and nitrated benzoate structure makes it a critical building block for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the nitro and halogen substituents for bioactivity.
• Liquid Crystal & OLED Material Research: Serves as a building block for advanced organic electronic materials due to its aromatic core and functional group versatility.
• Dye & Pigment Intermediate: Employed in the production of specialized dyes and pigments where the nitro group is integral to color development.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Chloro-4-Fluoro-5-Nitro-Benzoic Acid Methyl Ester
CAS No.	1529446-36-3
Molecular Formula	C8H5ClFNO4
Molecular Weight	233.58 g/mol
Synonyms	Methyl 3-Chloro-4-fluoro-5-nitrobenzoate; Benzoic acid, 3-chloro-4-fluoro-5-nitro-, methyl ester; 3-Chloro-4-fluoro-5-nitrobenzoic acid methyl ester; Methyl 3-chloro-4-fluoro-5-nitrobenzoate; 1529446-36-3; 3-Chloro-4-fluoro-5-nitro-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoro-5-Nitro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment supports applications requiring GMP-grade starting materials and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.