Description

4-Bromo-2-Chloro-5-Iodo-Benzoic Acid Methyl Ester is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters because its unique halogen pattern provides multiple, orthogonal sites for selective functionalization, enabling the efficient construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a key intermediate in cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Serves as a versatile precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring complex halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the halogen substituents influence biological activity and stability.
• Material Science Research: Acts as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings, leveraging the bromo and iodo groups for sequential functionalization.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies and library synthesis to explore new chemical space for lead optimization.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Details
Product Name	4-Bromo-2-Chloro-5-Iodo-Benzoic Acid Methyl Ester
CAS No.	1529124-65-9
Molecular Formula	C8H5BrClIO2
Molecular Weight	374.39 g/mol
Synonyms	Methyl 4-Bromo-2-Chloro-5-Iodobenzoate; Benzoic acid, 4-bromo-2-chloro-5-iodo-, methyl ester; 4-Bromo-2-chloro-5-iodobenzoic acid methyl ester; Methyl 4-bromo-2-chloro-5-iodobenzoate; 1529124-65-9; 4-Br-2-Cl-5-I-Benzoic Acid Me Ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-5-Iodo-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.