Description

Methyl trans-3-Bromocyclobutane-1-Carboxylate is a high-purity, synthetically valuable brominated cyclobutane derivative. This compound serves as a versatile and critical pharmaceutical intermediate and organic building block for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as medicinal chemistry, cross-coupling reactions, and ring-expansion studies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules, particularly those containing strained ring systems.
• Suzuki-Miyaura Cross-Coupling: Serves as an electrophilic partner for palladium-catalyzed coupling reactions to introduce the functionalized cyclobutyl moiety into more complex structures.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and scaffold hopping to explore structure-activity relationships (SAR) due to its unique four-membered ring geometry.
• Agrochemical Synthesis: Building block for developing new crop protection agents with novel modes of action.
• Material Science Research: Monomer or precursor for synthesizing polymers and advanced materials with specific thermal or mechanical properties.
• Ring-Opening and Expansion Reactions: Substrate for studying the reactivity of strained carbocycles to access larger ring systems or functionalized linear chains.

Basic Information

Product Name	Methyl trans-3-Bromocyclobutane-1-Carboxylate
CAS No.	1523618-35-0
Molecular Formula	C7H9BrO2
Molecular Weight	205.05 g/mol
Synonyms	trans-Methyl 3-bromocyclobutanecarboxylate; Methyl (1r,3r)-3-bromocyclobutanecarboxylate; 3-Bromocyclobutanecarboxylic acid methyl ester; (trans)-3-Bromocyclobutanecarboxylic Acid Methyl Ester; Methyl 3-bromocyclobutanecarboxylate (trans); Cyclobutanecarboxylic acid, 3-bromo-, methyl ester, trans-; Methyl trans-3-bromocyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl trans-3-Bromocyclobutane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR analysis, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Isomeric Purity (trans)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.