Description

5-Aza-Spiro[3.4]Octane-2-Carboxylic Acid Hydrochloride is a high-value, nitrogen-containing spirocyclic building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research, particularly in the development of novel small molecule therapeutics targeting a range of diseases. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key scaffold for constructing novel drug candidates in medicinal chemistry programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Serves as a core structure for creating tool compounds to study biological pathways and enzyme function.
• Agrochemical Research: Potential intermediate in the synthesis of new active ingredients for crop protection.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and novel synthetic route exploration.
• Peptidomimetic Design: The spirocyclic structure mimics peptide turn motifs, useful in designing stable peptide analogs.

Basic Information

Product Name	5-Aza-Spiro[3.4]Octane-2-Carboxylic Acid Hydrochloride
CAS No.	1523606-22-5
Molecular Formula	C8H12N2O2 • HCl
Molecular Weight	204.65 g/mol (Free base: 168.19 g/mol)
Synonyms	5-Azaspiro[3.4]octane-2-carboxylic acid hydrochloride; 2-Carboxy-5-azaspiro[3.4]octane hydrochloride; 5-Aza-spiro[3.4]octane-2-carboxylic acid HCl; 1523606-22-5; 5-Azaspiro[3.4]octane-2-carboxylic acid, hydrochloride; Azaspirooctanecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our production of 5-Aza-Spiro[3.4]Octane-2-Carboxylic Acid Hydrochloride adheres to stringent internal quality standards, ensuring batch-to-batch consistency for research and development applications. All materials are fully characterized and undergo rigorous analytical testing. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.